Which of the following practices should be avoided when formatting an Excel spreadsheet?

Excessive use of italics and underlines can lead to accessibility issues within Excel spreadsheets. When too many elements are emphasized through italics or underlines, it can create a visual distraction and hinder readability. This is particularly challenging for individuals with visual impairments or those who rely on screen readers.

In contrast, using descriptive labels and descriptions, as well as employing simple tables for data, enhances comprehension and organization. Providing meaningful hyperlink text is also crucial, as it allows users to understand what to expect when they click a link. Overall, avoiding excessive italics and underlines is essential for creating clear, understandable, and accessible spreadsheets.